The researchers of the study found that T-follicular helper cell response to the flu vaccine is greatest during the first trimester.
The study involved 36 pregnant women during the flu season between 2012 and 2014. The women were administered inactivated influenza vaccines, and blood samples were taken prior to vaccination and 14 days after vaccination.
Presenter of the study Emily Patel said, “The study results suggest that immunological changes during pregnancy may affect the response to the vaccination. Future studies will lead to a better understanding of vaccine immunology, and how pregnant women respond to antigen exposure through the course of their pregnancy.”
Sources:
http://www.eurekalert.org/pub_releases/2016-02/sfmm-eoi020116.php