In multiple sclerosis, dietary fatty acids effect on gut immune system may affect progress

Written by Emily Lunardo
Published on

In multiple sclerosis, dietary fatty acids effect on gut immune system may affect progressThe progression of dietary fatty acids in multiple sclerosis, an autoimmune chronic-inflammatory disease, have been found to support the immune system. The research comes from a collaboration between the Departments of Neurology at the Ruhr-Universität Bochum (St. Josef-Hospital) and the Friedrich Alexander University Erlangen. The researchers uncovered that long-chain fatty acids support the development and spreading of central nervous system reactive immune cells in the intestinal walls. Short-chain fatty acids, on the other hand, support the development and spreading of regulatory cells.

Research in the medical community has largely become focused on the gut and its bacterial contents, especially regarding its role in neurological disorders such as multiple sclerosis. The latest findings further reveal how the gut microbiome plays a role in the progression of disease. Diet is a large part in this connection as it can greatly affect the gut microbiome.

Researchers revealed in culture cell dishes and experimental models that long-chain fatty acids promote the spread of inflammatory cells in the intestinal wall. They also discovered that short-chain fatty acids produce further regulatory cells of the immune system. These cells have the ability to regulate excessive inflammatory responses and autoreactive immune cells.

Researchers did not uncover any effects of dietary fatty acids when the intestines were germ-free. Further experimentation revealed that the metabolic processes of the microbiome are responsible, as opposed to bacterial strains for this effect.

Assumptions have been made, about autoimmune chronic-inflammatory diseases like multiple sclerosis, that an imbalance between weakened regulatory cells and inflammatory cells is responsible for their development. Instead of using treatment to block or weaken inflammatory cells, treatment should focus on strengthening and boosting regulatory cells.

The findings were published in Immunity.

Also Read : Multiple sclerosis relapse risk influenced by melatonin levels
Multiple sclerosis (MS) cognitive dysfunction problems and mood disorders
Know all about MS: Multiple sclerosis


Source:
http://www.sciencedaily.com/releases/2015/10

Advertisement

On any matter relating to your health or well-being, please check with an appropriate health professional. No statement herein is to be construed as a diagnosis, treatment, preventative, or cure for any disease, disorder or abnormal physical state. The statements herein have not been evaluated by the Foods and Drugs Administration or Health Canada. Dr. Marchione and the doctors on the Bel Marra Health Editorial Team are compensated by Bel Marra Health for their work in creating content, consulting along with formulating and endorsing products.

Exit mobile version