Kidney disease risk higher in postmenopausal women undergoing long-term estrogen treatment

Kidney disease risk increases in postmenopausal women undergoing long-term estrogen treatment. Estrogen is known to offer protective effects against high blood pressure, but as the estrogen levels decrease after menopause the benefits decrease as well.

The researchers bred rats to mimic gender-specific blood pressure differences commonly observed in humans to determine whether hormone therapy negatively impacts the kidneys.

The researchers studied three groups of middle-aged rats without ovaries. One group was given estrogen for the short term, the second received longer estrogen treatment, and the third (control group) didn’t receive estrogen.

The researchers found that after hormone therapy, those mice that had a long-term treatment had greater damage to the tubes that collect urine, compared to the other two groups. The rate at which the kidneys filtered blood decreased, while the levels of creatinine and protein in the urine increased.

The researchers explained, “[The] findings suggest that the duration of hormone therapy may be an important factor for renal health in aging postmenopausal women.”

Kidney disease prevalence in women

Although there is a higher prevalence of kidney disease in women, research has shown that men are more likely to receive life-saving dialysis. Researchers looked at data from over 200,000 patients receiving dialysis from 12 countries. Men were more likely to receive dialysis sooner and were more likely to be on dialysis overall, even with advanced kidney disease.

Nephrologist Beth Piraino explained, “I think it raises very interesting questions, but I don’t think it answers them. I think it could be explored in more detail in each of these individual countries. The reason it’s true in the United States might not be the reason it’s true in Sweden.”

Why the course of treatment for men and women with kidney disease varies is not well understood, but some researchers speculate it may have to be due to biological differences, disease progression differences, and that women may be offered dialysis less often than men.

Women are often more proactive when it comes to seeking care for their health, while men won’t often be diagnosed with kidney disease until the later stages.

To better understand such differences, further investigation is required.