Lithium is being touted as a way to restore basic biological processes in human cells and animal models, according to researchers at the Children’s Hospital of Philadelphia.
“By adjusting basic biological activities involved in cell death and energy production, we were able to rebalance cells toward more normal functioning,” said Marni Falk, of the hospital’s Mitochondrial-Genetic Disease Clinic.
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She said she hopes the results of the study will help develop effective new treatments for patients with mitochondrial disorders.
Mitochondria are the tiny structures that supply energy to our cells. Any malfunction can lead to mitochondrial disorders that are very complex. Once the cellular energy flow is impaired, it will directly affect the tissues and organs. And the main organs and tissues like the brain, heart and the muscles will start malfunctioning. More often than not, these disorders have no cures and few effective treatments.
In addition to the malfunctioning of the tissues and organs, and other mitochondrial disorders, abnormal mitochondria can also help cause common conditions, such as Type 2 diabetes, epilepsy, Parkinson’s disease, and even human aging.
In the current study the researchers investigated two of the basic biological processes regulated by mitochondria – protein translation and autophagy. Protein translation is the process by which proteins, specified by the genetic code in DNA and RNA, are produced by the cells. Autophagy is a self-maintenance mechanism by which cells digest their own components.
In mitochondrial disorders, both of these processes run out of control and result in the accumulation of potentially toxic proteins in the cells, leading to disease symptoms, and in cases even cell death.
“Both of these cellular activities are abnormal in mitochondrial disease,” said Falk. “When we were able to slow down either or both of these basic processes, we improved mitochondrial disease symptoms in laboratory animals and in human patient cells.”
While inhibiting either of the processes is helpful in limiting disease, the authors of the study said they feel that the most striking effects resulted from treating the cells with drugs that partially inhibited both protein translation and autophagy. The study revealed that lithium chloride, and the antibiotic, cycloheximide, improved viability and cellular respiratory function.
Falk said she hopes the current findings will open “a new arsenal of therapies” for patients with mitochondrial disease.
Thanks to this new-found knowledge, early-stage clinical research trials are being planned by the Mitochondrial Disease Clinical Center at CHOP to pharmacologically target the cellular consequences of mitochondrial disease.
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The study was published online in the June 3 edition of Human Molecular Genetics.
Image: The red fluorescent areas in this image of the microscopic worm C. elegans mark free radicals that build up in worms with mitochondrial disease. Photo courtesy The Children’s Hospital of Philadelphia.
Source:
http://www.eurekalert.org/pub_releases/2015-07/chop-nte071715.php
Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.
