For those who suffer from an overactive bladder, the FDA may be offering hope with a new mode of treatment. The agency has just recently approved a supplemental New Drug Application (sNDA) for mirabegron (Mybetriq) as a combination therapy with muscarinic antagonist solifenacin succinate (VESIcare) for the treatment of overactive bladder (OAB).
The new treatment was added to the list of other combination therapies to treat symptoms of OAB.
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Approval was based on results of a three-phase trial. In SYNERGY 1 and 2, which included over 9,000 patients who were administered either mirabegron and solifenacin succinate, monotherapy of either drug or placebo, to test for safety profile.
For phase three of the BESIDE study, 2,174 patients were enrolled from 31 countries to study efficiency. They received the set-dose regimen versus sole doses of 5 mg and 10 mg solifenacin succinate.
There is a strong need to develop effective treatments for overactive bladder as cases are on the rise. An estimated 546 million people are affected by OAB in a year.
When the bladder sends wrong signals to the brain, that triggers the urgency to urinate regardless if the bladder is full or not.
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Carol Schermer from Astellas Pharma concluded, “OAB patients may have symptoms that are not fully managed with their current treatment. With the FDA approval of Myrbetriq in combination with solifenacin succinate, Astellas is able to offer an additional treatment option to individuals living with symptoms of OAB.”
In the meantime, if you suffer from overactive bladder, it’s important to speak to your doctor as some treatments are currently available that may offer you some form of relief.
Also read: Natural bladder supplements: 18 herbal remedies for overactive bladder
Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.
